Jente Lu

Ph. D. Candidate

Department of Biomedical Engineering

University of California at Irvine

Research Interests

       · Microfluidics applications

       · Stem Cell Sorting for Regenerative Medicine

       CFD simulation

       · Biomaterial for Tissue Engineering

       · Bioprocess Development: Bioreactor Optimization & Protein Purification.

Contact Information

Department of Biomedical Engineering & 

Department of Pathology and Laboratory Medicine

University of California at Irvine

3200 Gross Hall - FLANAGAN LAB - 3rd Floor

845 Health Sciences Road 

Irvine, CA 92697-0001

United States

Tel:   (949) 824-0245

Fax:  (949) 824-2160

Email: jentel@uci.edu

            kent.jentel@gmail.com

Web:  Linkedin profile

Education and Position

       2009-present     Pre-doctoral Fellow, California Institute for Regenerative Medicine, San Francisco

       2007-2008         Roman Reed Fellow, Roman Reed Center, Irvine

       2006                  M.S., Chemical and Biochemical Engineering, University of California, Irvine

       2003                  B.S., Chemical Engineering & minor in Life Science, NTHU, Taiwan

Professional Certifications and Societies

      2009-present   Student Member, International Society for Stem Cell Research

      2008-present   Student Member, Society for Biological Engineering

      2007-2009     Student Member, Biomedical Engineering Society

      2008-2009     Student Member, Society for micro total analysis system

      Feb. 2010      Certificate in Human ES cell culture, UCI Stem Cell Core, Irvine

      Aug. 2009      Certificate in CFD-ACE+ Introductory Training, ESI group, Santa Clara

      1999-2003     Certificate in Biochemical Technology and Bio-Industry, NTHU, Taiwan

Publications

Selected Original Articles

J1. Hu, Y.C., Lu, J.T., Chung, Y.C., High-density cultivation of insect cells and production of recombinant baculovirus using a novel oscillating bioreactor. Cytotechnology 42(3): 145-153, 2003.

J2. Lu, J.T., Chung, Y. C., Chan, Z. R., Hu, Y. C., A novel oscillating bioreactor BelloCell: implications for insect cell culture and recombinant protein production. Biotechnol Lett 27(15): 1059-65, 2005.

J3. Flanagan, L.A.*, Lu, J.*,Wang, L.S, Marchenko, S.A., Jeon N.L., Lee A.P., Monuki, E.S., Unique dielectric properties distinguish stem cells and their differentiated progeny. Stem Cells 26(3): 656 - 665, 2008. *These two authors contributed equally to this work.

J4. Wang, L., Lu, J., Marchenko, S.A., Monuki, E.S., Flanagan, L.A., Lee A.P., Dual frequency dielectrophoresis with interdigitated sidewall electrodes for microfluidic flow-through separation of beads and cells. Electrophoresis 2009, 30, 1–10

J5. Huang, P.C., Lu, J., Seon, H.Y., Lee, A.P., Flanagan, L.A., Kim, H.Y., Putnam, A.J., Jeon, N.L.  Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip, 2009, 9(12): 1740-8.

J6. Labeed, F. H., Lu, J., Mulhall H., Marchenko, S.A., Hoettges, K.F., Hughes, M.P., Lee, A.P., Flanagan L.A. Biophysical characteristics reveal human neural stem cell differentiation potential.  (Submitted to PLoS ONE)

J7. Lu, J., Do, M., Nourse, J.L., Hughes, M.P., Lee, A.P., Flanagan L.A., Label free monitoring of stem cell differentiation using microfluidic dielectrophoresis trapping device.  (Submitted to Annals of Biomedical Engineering, Invited manuscript in UC bioengineering SI)

J8. Shepard, P.*, Choi, E.A.*, Lu, J., Flanagan, A.P., Hertel, K., Shi, Y.S., Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq. (Accepted by RNA) *These two authors contributed equally to this work.

J9. Lu, J., Barrios, C.C., Dickson, A., Nourse, J.L., Lee, A.P., Flanagan L.A. Dielectrophoric influence to Human and Mouse Neural Stem Cells: Implications for stem cell physiology and fate determination. (Manuscript in preparation)

Selected conference proceedings (peer reviewed)

C1.  Lu. J.T., Chun, Y.C, Hu, Y.C. High-density cultivation of insect cells and production of recombinant baculovirus using a novel oscillating bioreactor. 2003, Oral Presentation at the 8th Conference on Biochemical Engineering, Kaohsuing, Taiwan, ROC.

C2.  Flanagan, L.A., Lu, J., Wang, L.S., Marchenko, S.A., Jeon N.L., Lee A.P., Monuki E.S., Unique dielectric properties distinguish stem cells and their differentiated progeny. 2008, SBE's First International Conference on Stem Cell Engineering, San Diego, CA, USA. (Selected as Oral Presentation, present by Monuki E.S.)

C3.  Lu, J., Lee, A.P., Flanagan, L.A. Dielectrophoresis as a tool for sorting stem cells and their differentiated progeny. 2008, The Henry Samueli School of Engineering's Seventh Annual Industry Research Symposium "California: Prosperity Through Technology", Irvine, CA, USA. (The 2008 Fariborz Maseeh Best Research Poster)

C4.  Huang, P.C., Seon, H.Y., Lu, J., Putnam, A., Jeon, N.L. Engineering 3D microstructures for cell co-culture studies., 2008, The BMES Annual Fall Meeting, St. Louis, MO, USA.

C5.  Lu, J., Huang, C.P., Lull, G., Jeon N.L., Monuki. E.S., Flanagan L.A., Lee, A.P. A novel microfluidic device combining dielectrophoresis-based cell patterning and 3D biomaterials for simulating central nervous system lesion sites. 2008, The 12th International Conference on µTAS, San Diego, CA, USA.

C6. Labeed, F.H., Lu, J., Marchenko, S.A., Hoettges, K.F., Hughes, M.P., Monuki, E.S., Lee, A.P., Flanagan, L.A. A Microdevice To Indicate Human Neural Stem Cell Differentiation Potential. 2009, The Biophysical Society's 53^rd Annual Meeting, Boston, MA, USA.

C7.  Labeed, F.H., Lu, J., Marchenko, S.A., Hoettges, K.F., Hughes, M.P., Monuki, E.S., Lee, A.P., Flanagan, L.A. A Novel Biomarker to Human Neural Stem Cell Differentiation Potential. 2009, International Society for Stem Cell Research 7^th Annual Meeting, Barcelona, Spain.

C8.  Lu, J., Lee, A.P., Flanagan, L.A., Dielectrophoresis as a Novel Stem Cell Sorting Method: Implications for Stem Cell Survival, Proliferation, and Cell Cycle Kinetics, 2010, SBE's Second International Conference on Stem Cell Engineering, Boston, MA, USA.

C9.   Shepard, P.*, Choi, E.A.*, Lu, J., Flanagan, A.P., Hertel, K., Shi, Y.S., Transcriptome-wide Quantitative Analyses of RNA Polyadenylation in Mouse Embryonic Stem Cells and Differentiated Cells using Poly(A) Site Deep Sequencing (PAS-Seq), 2010, 8th Annual Institute for Genomics & Bioinformatics (IGB) Biomedical Informatics Training (BIT) Program Symposium, Irvine, CA, USA. *These two authors contributed equally to this work.

Abstracts/Presentations

A1.   Lu, J.T., Flanagan L.A., Wang, L.S., Marchenko, S.A., Jeon N.L., Lee, A.P., Monuki. E.S., A novel microfluidic system for sorting stem cells and their differentiated progeny. 2007, Roman Reed Research Meeting, Irvine, CA, USA.

A2.   Lu, J.T., Wang, L.S., Marchenko, S.A., Jeon N.L., Lee, A.P., Monuki. E.S., Flanagan L.A. Unique dielectric properties distinguish stem cells and their differentiated progeny. 2008, Roman Reed Research Meeting, Irvine, CA, USA.

A3.   Lu, J.T., Lee, A.P., Flanagan, L.A., Dielectrophoresis as a novel stem cell sorting method: Implications for cell survival, proliferation, and differentiation potential, 2010, CIRM Grantee meeting, San Francisco, CA, USA.