ALBERT TSUNG-HSI HSIEH

• Microfluidic Droplet Array Bioassays (DAB)- Nucleic acid, SNP, multiplex genes, protein, cell analysis
• Saliva diagnosis health monitoring (NASA)

• Picoliter Micro Reactor and Incubator (PMRI) assay

• Gene transfection/therapy(RNAi) - Optimize non-viral gene transfection carrier formulation
• Oncogene inhibitor and indicator - Bcr-Abl tyrosine kinases of Chronic Myelogenous Leukemia (CML)
• Integrated micro total analysis system. Droplet PCR bioassay. Integrated Sample-to-Answer microfluidic system for gene diagnostics.

Contact Information :

Biomedical Engineering Department
University of California, Irvine
3120 Natural Sciences II
Irvine, CA 92697-2715

Email: alhsiehuci@gmail.com

Education:

Ph.D., University of California, Irvine

M.S., University of Southern California, Los Angels

Recent Publications:

• Albert T. Hsieh, Patrick Pan, Abraham P. Lee, "A real-time characterization method to rapidly optimize molecular beacon signal for sensitive nucleic acids analysis", Analytical and Bioanalytical Chemistry, 2014. (10.1007/s00216-014-7721-z. vol. 406, no.13)

• Albert Tsung-Hsi Hsieh, Nicole Hori, Rustin Massoudi, Patrick Jen-Hao Pan, Hirotaka Sasaki, Yuh Adam Lin, Abraham P. Lee. Nonviral Gene Vector Formation in Monodispersed Picoliter Incubator for Consistent Gene Delivery. Lab Chip, (Accepted).

• Albert T. Hsieh, Patrick J. Pan, Abraham P. Lee, “Rapid label-free DNA analysis in picoliter microfluidic droplets using FRET probes”, Microfluidics and Nanofluidics, 10.1007/s10404-009-0406-9

• Albert Tsung-Hsi Hsieh, Jen-Hao Pan, Pablo G Pinasco, Jeff Fisher, Lung-Hsin Hung, Abraham P. Lee, "Polymer Microsphere Mass Production using 128-Channel Digital Fluidic Chip”, The Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2007), (Accepted) Paris, France, October 7-11, 2007

• Albert Tsung-Hsi Hsieh, Jen-Hao Pan, Abraham P. Lee, "Photobleaching Free DNA Hybridization Kinetics Evaluation Using Chemically Identical Repeating Microdroplet", The 2nd International Congress of Nanobiotechnology & Nanomedicine (NANOBIO 2007), p10-1~10-3, San Francisco, CA, June 18-21, 2007

• Albert Tsung-Hsi Hsieh, Yuh Adam Lin, Jen-Hao Pan, Abraham P. Lee "Monodisperse Liposomal Gene Carrier Formulation in Picoliter Micro-Reactor for Consistent and Efficient Gene Delivery", p.1369-1371, The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2006), Tokyo, Japan, Nov. 5-9, 2006.

• Albert Tsung-Hsi Hsieh, Jen-Hao Pan, Yuh Adam Lin, Abraham P. Lee "Evaluation of Hybridization Kinetics of Molecular Beacons Using Picoliter Microfluidic Droplet With Millisecond Resolution", p.1321-1323, The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2006), Tokyo, Japan, Nov. 5-9, 2006.

• John Collins, Jeff Fan, Reza Moghbel, Albert Tsung-Hsi Hsieh, Abraham P. Lee
  "Laminar Flow Mixing using Acoustic Microcavitation Streaming", p.116-118, The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2006), Tokyo, Japan, Nov. 5-9, 2006.

• Albert Tsung-Hsi Hsieh, Adam Yuh Lin, Abraham P. Lee "Size Discrete Lipoplex Fabrication by Picoliter Incubator for Improving Gene Transfection", International Symposium on LifeChips, 2006, Beckman Center of the National Academies of Science and Engineering, UC Irvine, USA, May 16-17, 2006.

• Albert Tsung-Hsi Hsieh, Adam Yuh Lin, Abraham P. Lee "Non-Viral Liposomal Carrier Fabrication by Integrated Micro-mixer and Micro-incubator System" 5th Annual Industry Research Symposium, California Prosperity Through Technology, UC Irvine, May 15-17, 2006.

• Albert Tsung-Hsi Hsieh, Adam Yuh Lin, Abraham P. Lee "Monodisperse Lipoplex Generation by Integrated Picoliter Micro Reactor and Incubator" p.158-161, IEEE-International Conference on Microtechnologies in Medicine and Biology, Okinawa, Japan, May 9-12, 2006.

• Abraham P. Lee; Yung-Chieh Tan; John Collins, Lung-Hsin Hung; Tsung-Hsi Hsieh
  "Micro and nano fluidic chips for biosensors" p.32-36, IEEE Sensors, Oct. 2005.

• Albert Tsung-Hsi Hsieh, Lung-Hsin Hung, and Abraham P. Lee, "Rapid Breast Cancer Gene Detection in Picoliter Droplet" p.1327-1329, The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2005), Boston, Oct.9-13, Boston.

• Lung-Hsin Hung, Albert Tsung-Hsi Hsieh, Nate Portney, and Abraham P. Lee,
  "Microfluidic-Based PLGA Nanosphere Generator For Protein Coating", p.1218-1220, The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2005), Boston, p.1218-1220, Oct.9-13, Boston.

• Asheesh Divetia, Tsung-Hsi Hsieh, Jun Zhang, Zhongping Chen, Mark Bachman, and Guann-Pyng Li "Dynamically focused optical coherence tomography for endoscopic applications" p.103902-1~103902-3, Applied Physics Letters, 86 (10): Mar, 2005.

• James Webster, K. Y. Weng, W. C. Chang, Tsung-Hsi Hsieh, C. J. Chang, C. W. Wang, and C. K. Chung "A Hybrid Micromachining Process for DNA Biochip Applications" p.3-43 ~ 3-50, The 4th Nano Tech and Microsystems Technology Conference, Taiwan 2000.

• K. Y. Weng, C. K. Chung, Tsung-Hsi Hsieh, and H. C. Lu "ICP LIGA-like Processes", p.124-128, The Cross Strait Microsystems Conference, 2000, Taiwan.

Honors:

• 2006 Elected as Calit2 Emulex Fellow. The Emulex Fellowship of The California Institute for Telecommunications and Information Technology (http://calit2.net/newsroom/article.php?id=866)
• 2006 University of California Regents Fellowship
• 2005 University of California Regents Fellowship
• 2002 University of California Regents Fellowship

Interests:

Reading, Travel, Photography, Guitar, Harmonica, Badminton, Tae-Kwon-Do & Billiards.